Sos anticorps

N° du produit ABIN302096

L’anticorps Souris Monoclonal anti- a été validé pour WB et ICC. Il convient pour détecter dans des échantillons de Humain, Souris et Non-Human Primate.

Aperçu rapide pour Sos anticorps (ABIN302096)

Antigène: Sos

Reactivité: Humain, Souris, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Clone: SOS-01

Détail du produit

Fonction: Anti-SOS Purified

Specificité: The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.

Réactivité croisée (Details): Human, Mouse, Other not determined

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.

Isotype: IgG1

Information d'application

Indications d'application: Western blotting: Recommended dilution: 1 μg/mL, positive control: HeLa human cervix carcinoma cell line, reducing conditions.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détail du antigène

Antigène: Sos

Sujet: SOS Ras/Rac guanine nucleotide exchange factor 1,The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.,SOS1, HGF, GGF1

ID gène: 6654

UniProt: Q07889